TRAF2 is required for survival via NF-κB and memory cell generation whereas TRAF5 seems to have a more negative or modulatory role, as knockouts have higher levels of cytokines and are more susceptible to Th2-meditated inflammation.
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OX40 binds TRAF2, 3 and 5 as well as PI3K by an unknown mechanism.
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TRAF3 may play a critical role in OX40-mediated signal transduction.