CRKL and MAPK1 genes have been suggested to have a role in the heart anomalies that are common in 22q11.2 distal deletion syndrome.
DCrk (Drosophila ortholog of Crk) is the Drosophila melanogaster ortholog of the mammalian proteins Crk and CrkL.
The YXXP binding motif is required for the association of CRKL and GAB2.