Up to 7% of Caucasians are poor metabolizers of drugs metabolized by the CYP2D6 enzyme.
CYP2D6 |
The drugs and the enzymes they probe are as follows - caffeine (probes CYP1A2, N-acetyltransferase 2, xanthine oxidase), midazolam (probes CYP3A), omeprazole (probes CYP2C19) and dextromethorphan (probes CYP2D6).