It can still be transited by visitors to the Cabeza Prieta National Wildlife Refuge, established in 1939 to protect desert wildlife.
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Today, the Camino Del Diablo crosses the southern edges of Organ Pipe Cactus National Monument, Cabeza Prieta National Wildlife Refuge, and the Barry M. Goldwater Air Force Range, terminating at Yuma, Arizona.
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In 1939, after intense lobbying by Frederick Russell Burnham and the Arizona Boy Scouts, President Franklin D. Roosevelt signed a proclamation to establish two desert areas in southwestern Arizona to help preserve the desert bighorn sheep: Cabeza Prieta National Wildlife Refuge and the Kofa National Wildlife Refuge.