In the early 21st century, a Georgia botanist Jim Allison discovered eight unknown flower species, and later eight more were identified along the river's course that previously had not been sited in the state of Alabama.
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The round rocksnail was historically found in the Cahaba River and the Little Cahaba River, Bibb County, Alabama; and the Coosa River, Elmore County, Alabama, and tributaries—Big Canoe and Kelly's creeks, St. Clair County, Alabama; Ohatchee Creek, Calhoun County, Alabama; Yellowleaf Creek, Shelby County, Alabama; and Waxahatchee Creek, Shelby/Chilton counties, Alabama.
The Cahaba River Wildlife Management Area is an Alabama Wildlife Management Area (WMA) operated by the Alabama Department of Conservation and Natural Resources in Bibb and Shelby Counties near West Blocton, Alabama.
The flat pebblesnail has not been found in the Coosa River portion of its range since the construction of the Lay Dam and Logan Martin Dam, and recent survey efforts have failed to locate any surviving populations outside of the Cahaba River drainage.