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It rises in the Abruzzese central Apennines of Samnium near Castel San Vincenzo (province of Isernia, Molise) and flows southeast as far as its junction with the Calore River near Caiazzo and runs south as far as Venafro, and then turns southwest, past Capua, to enter the Tyrrhenian Sea in Castel Volturno, northwest of Naples.