The town is mentioned for the first time in 1141 in a document mentioning several Arabic localities, a sign that it was settled at least from the Islamic domination of the island.
He was the only son born to first generation emigrants, a Mr. Scibetta from Cammarata in the province of Agrigento, Sicily and an Italian-American woman Mrs. Zicarelli from Bayonne, New Jersey.
Santo Stefano Quisquina stands at an altitude of 730 metres above sea level and borders the following municipalities: Alessandria della Rocca, Bivona, Cammarata, Casteltermini, Castronovo di Sicilia, San Biagio Platani.