Most recently she executive produced Nurse Jackie, with Linda Wallem and Liz Brixius, a half-hour dark comedy about a "flawed" emergency room nurse in a New York City hospital, starring Edie Falco, which is a hit on Showtime in America, and on BBC2 in the UK.
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Caryn Mandabach produced ground-breaking US hits including The Cosby Show, Roseanne, A Different World (1990–1993), Grace Under Fire (1993–1998), Cybill (1995–1998), 3rd Rock from the Sun (1997–2001), That '80s Show (2002), That '70s Show (1998–2004), and Grounded for Life (2001–2005).