The series revolves around Cat and Dog, who share the same body, and although they are best friends and brothers, they have very different personalities, similar to The Odd Couple mixed with elements of Laurel and Hardy and Abbott and Costello.
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Sunshine (voiced by Billy West) is a green-skinned, shirtless humanoid creature with a thin, once-coiled tail and no apparent emotions, who has a monotone voice and demeanor very similar to the actor Ben Stein.
The week of June 3–6, 2013 was branded "Summer Blockbusters" and features television movies based on 1990s Nickelodeon series, including Rugrats: "Runaway Reptar", Kenan & Kel: "Two Heads Are Better Than None", CatDog: "The Great Parent Mystery", and Kenan & Kel: "Awww Here it Goes to Hollywood".