The upper Chagres River, its watershed, and the watershed of several tributaries lie within the Chagres National Park, created in 1985 to preserve the flow of water into the canal.
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Goods were transported on foot from Panama City to the coastal town of Cruces, and from there by sailboats on the river all the way to its mouth.
From 1850 to 1853 he engaged with his brother in operating a steamboat line upon the Chagres River, Isthmus of Panama.
After recovering his health, Hollenbeck took a position as an engineer on a steamer running up the Chagres River.
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Although Chagres fell outside the original boundary of the Panama Canal Zone, that boundary was expanded in 1916 to include the Chagres River's mouth.