Charles Horace Mayo (July 19, 1865 – May 26, 1939) was an American medical practitioner and was one of the founders of the Mayo Clinic along with his brother, William James Mayo, Augustus Stinchfield, Christopher Graham, E. Star Judd, Henry Stanley Plummer, Melvin Millet and Donald Balfour.
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His two sons Charles William Mayo and Joseph Graham Mayo both worked at the clinic.
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Fenger's lectures were very popular, and over the years, he trained several prominent physicians, including William James Mayo, Charles Horace Mayo, Nicholas Senn, James B. Herrick, Ludvig Hektoen, and Howard Taylor Ricketts.