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In 1528 the Genoese Admiral, Andrea Doria, after deserting in favour of Charles, managed to break up the French siege of Naples; his efforts were helped by the plague, which decimated the French besiegers, among them General Odet of Foix, Viscount of Lautrec, who died on 15 August.
The House of Olivares was constituted in 1539 when Charles I of Spain granted Pedro Pérez de Guzmán, son of Juan Alfonso Pérez de Guzmán, 3rd Duke of Medina Sidonia, the title of Count of Olivares (Sp. conde de Olivares).
In 1520 he joined the Spanish army of Charles I and fought in Flanders in 1521 and Italy between 1522 and 1525, participating in the battle of Pavia as part of the troops of the Marquis of Pescara.
It was made prior to its subject's marriage to Ferdinand III of Austria to be taken to Spain as a reminder of her in her absence for her brother Philip IV of Spain (since the time of Charles I of Spain it had been customary for Spanish kings and their relatives to exchange kinship portraits to show their character to others, to demonstrate their appearance in marriage negotiations or simply to remind each other of their appearance).
Hernando Dávalos made part of the well documented Toledo "Comuneros" fighting against the extra tax contributions, circa 1518, asked for by king Charles I of Spain (Holy Roman Emperor Charles V) to bend the wishes of the German Electors in his wishes of becoming a Holy Roman Emperor.
Apparently, this title was awarded again by king Charles I of Spain, a.k.a. Holy Roman Emperor Charles V to Rodrigo Pacheco.
Governorate of New Andalusia, in South America, created as one of the 1534 grants of Charles I of Spain