Its headwaters are in the Appalachian Mountains where it flows northwest near Robbinsville, to the Santeetlah Reservoir and flows towards the Tennessee border with a terminus at the Little Tennessee between the Cheoah Dam and Lake Calderwood.
The Junaluska salamander (Eurycea junaluska) was first described by David M. Sever, who found the species in the range from the Cheoah River, Santeetlah Creek, and Tululah Creek in Graham County of North Carolina.
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