He offered an enormous amount of money for the erection of middle level schools in Constantinople, the one (Zographeion Lyceum) in the district of Beyoğlu (Pera) in Constantinople and the other a female school in Yeniköy on the Bosporus, both schools were called 'Zografeion' after him.
He was the son of the entrepreneur and benefactor Christakis Zografos, from Qestorat, (Lunxhëri) in the Gjirokastër prefecture.
Christakis Zografos, who was living in Paris at the time, made the largest contribution, of 10,000 gold liras.
The College was a field of Greek-Albanian cultural conflict: on the one hand, Christakis Zografos, founder and supporter of the area's Greek character and the spread of Greek education and on the other hand, Koto Hoxhi, figure of the Albanian National Awakening.
When the Great Powers decided to award Northern Epirus to Albania, local Greeks formed a provisional government under Christakis-Zografos on February 28, 1914 and declared their autonomy the following day in Gjirokastër.