German sexologist Volkmar Sigusch may have been the first to use the term cissexual (zissexuell in German) in a peer-reviewed publication: in his 1998 essay "The Neosexual Revolution", he cites his two-part 1991 article "Die Transsexuellen und unser nosomorpher Blick" ("Transsexuals and our nosomorphic view") as the origin of the term.
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Julia Serano has defined cissexual as "people who are not transsexual and who have only ever experienced their mental and physical sexes as being aligned", while cisgender is a slightly narrower term for those who do not identify as transgender (a larger cultural category than the more clinical transsexual).