Clonal plants of colstfoot free of pyrrolizidine alkaloids were then developed in Austria and Germany.
clonal colony | Clonal colony | Clonal |
Clonal Anergy theory, proposed by Nossal, in which self-reactive T- or B-cells become inactivated in the normal individual and cannot amplify the immune response.
During the mid-1980s to early 1990s, a highly virulent clonal group of Haemophilus aegyptius, localized in and around the São Paulo State of Brazil, was found to be responsible for Brazilian purpuric fever, an acute septicemic fulminant illness affecting children.
Jerne developed the "natural selection theory of immunology," proposed by Paul Ehrlich 50 years earlier, although he was missing the clonal selection element proposed by David Talmage and then by Frank Macfarlane Burnet.
Among his many scientific contributions is the development of the two-stage clonal expansion (TSCE) model of carcinogenesis, also known as the Moolgavkar-Venzon-Knudson (MVK) model, a stochastic cell-level description of carcinogenesis based on Alfred G. Knudson’s two-hit hypothesis.