Commelina sphaerorhizoma is found in south-central Africa and is currently known only from the southerneastern part of the Democratic Republic of the Congo, specifically in Haut-Katanga District around the town of Gombela and in the Kundelungu National Park.
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This blue-flowered herb has been recorded only from the Haut-Katanga District of the Democratic Republic of the Congo, although at the time of its description it was known only from 3 collections.