Comptonia peregrina is used as a food plant by the larvae of some Lepidoptera species, including Bucculatrix paroptila, Grey Pug, Setaceous Hebrew Character, Io moth, and several Coleophora case-bearers: C. comptoniella, C. peregrinaevorella (which feeds exclusively on Comptonia), C. persimplexella, C. pruniella and C. serratella.