The bull gave Jews three months to leave the Papal States (with the exception of Rome, Ancona, and the Comtat Venaissin of Avignon).
In 1096, the Comtat was part of the Margraviate of Provence that was inherited by Raymond IV, Count of Toulouse from William Bertrand of Provence.
Fléchier was born at Pernes-les-Fontaines, in the département of Vaucluse, in the Comtat Venaissin, and brought up at Tarascon by his uncle, Hercule Audiffret, superior of the Congrégation des Doctrinaires.
The papal city of Avignon remained faithful in the bloody Wars of Religion that had broken out in earnest in 1562, but in the surrounding Venaissin the Huguenots were solidly implanted in Orange and the neighboring Dauphiné, and fierce fighting ensued.
One specific bequest in Alphonse's will, giving his wife's lands in the Comtat Venaissin to the Holy See, was allowed, and it became a Papal territory, a status that it retained until 1791.