One of these heirs was Edward of Pfalz-Simmern, Count Palatine and his daughter Anne, because she was a great-granddaughter of Charles of Lorraine, Duke of Mayenne through her mother Anna Gonzaga.
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This creation became extinct in 1688, and the lands passed to Anne, Pfalzgravine of Simmern, a great-granddaughter of Charles of Lorraine, Duke of Mayenne (whose mother happened to have first married the 5th Duke of Guise) – although she was not the heiress in primogeniture, that being the Duke of Mantova and Montferrat.
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