It now resides in Cross Street, between where Mrs Gaskell's husband's Unitarian Cross Street Chapel used to stand, and the little graveyard of St Ann's Church where Thomas de Quincey's forebears are buried, and in whose font Thomas de Quincey was himself christened.
Gaskell became the minister of Cross Street Chapel in Manchester in 1828, a position he held for sixty years.
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Leaving York at midsummer 1810, he preached for a few months at the Octagon Chapel, Norwich, and was invited to settle there as colleague to Theophilus Browne; but on 19 December 1810 he was called to Cross Street Chapel, Manchester, in succession to Ralph Harrison, and as colleague to John Grundy.
He died at 35 Acomb Street, Greenheys, Manchester, on 21 April 1854, and was buried on 26 April in the Rusholme Road cemetery; there was a brass to his memory in Cross Street chapel.