The war waged by the Tamoyo Confederation was strongly affecting the Portuguese colonisation efforts, so the two Portuguese Jesuit priests who had founded São Paulo dos Campos de Piratininga (which became the present-day megalopolis of São Paulo), Manoel da Nóbrega (1517–1570) and José de Anchieta (1534–1597) started a peace mission by doing a high risk visit to Cunhambebe's village.
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Cunhambebe (more correctly pronounced Quonambec in his native Tupi language) was an aboriginal Indian chieftain of the Tupinambá tribe, which dominated the region between present-day Cabo Frio (Rio de Janeiro) and Bertioga (São Paulo).