Especially the mechanism of action of benzo(a)pyrene-related DNA modification is well investigated and relates to the activity of cytochrome P450 subclass 1A1 (CYP1A1).
Unusual formal oxidation states of metals are important in biochemical processes, the notable ones being Fe(IV) and Fe(V) in Cytochrome P450-containing systems.
cytochrome b | cytochrome ''b'' | Cytochrome c oxidase | cytochrome c oxidase | cytochrome ''c'' oxidase | Cytochrome P450, family 1, member A1 | Cytochrome P450 | cytochrome P450 | Cytochrome c oxidase subunit I |
These compounds model biological complexes such as cytochrome P450, NO synthase, and isopenicillin N synthase.
Five missense mutations (A284P, R454H, V489E, C566Y, and V605F) and a splicing mutation in the POR genes have been found in patients who had hormonal evidence for combined deficiencies of two steroidogenic cytochrome P450 enzymes - P450c17 CYP17A1, which catalyzes steroid 17α-hydroxylation and 17,20 lyase reaction, and P450c21 21-Hydroxylase, which catalyzes steroid 21-hydroxylation.