He was a Member of Parliament and in 1932 he briefly became Minister of Finance.
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He continued working at his family’s cigarette factories (Kyriazi Freres) and, together with his brother Costadinos, opened custom-built factories in Amsterdam and Hamburg.
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Damianos Kyriazis was the first-born son of Ioannis Kyriazis (1853-1919), one of five brothers from Kissos, Greece, who founded the cigarette empire Kyriazi Freres.