In 2012, he was cast in his first teleserye project, Princess and I, top-billing with Kathryn Bernardo, Daniel Padilla and Enrique Gil.
Daniel Boone | Daniel Webster | Daniel Patrick Moynihan | Daniel Barenboim | Daniel Defoe | Daniel Amos | Daniel | Daniel O'Connell | Daniel Libeskind | Daniel Craig | Jack Daniel's | Daniel Radcliffe | Daniel Chester French | Daniel Boulud | Daniel Dennett | Daniel Day-Lewis | Daniel Collopy | Daniel Buren | Daniel Auber | Daniel Johnston | Daniel Ellsberg | Daniel Stern | Daniel O'Donnell | Daniel Burnham | Daniel Nestor | Daniel Henney | Daniel Boone (TV series) | Juan de Padilla | Daniel Spoerri | Daniel Menche |
After the progression, Loyzaga did several guesting including in the variety talk show, Gandang Gabi, Vice!, where he chaperoned Daniel Padilla and Neil Coleta.