Nalin and his colleague, Richard A. Cash, working in an adverse research climate,working in a tent housing patient overflow, at a small missionary hospital carved out of the jungle, fought to perform scientific trials that would prove Oral rehydration therapy would work.
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Nalin had the key insight that Oral rehydration therapy (ORT) would work if the volume of solution patients drank matched the volume of their fluid losses, and that this would drastically reduce or completely replace the only current treatment for cholera, intravenous therapy.
The 2006 Prince Mahidol Prize was awarded jointly to Dr. Richard A. Cash of Harvard School of Public Health, Dr. David Nalin and Dr. Mahalanabis.
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