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In 1992 he won the David di Donatello for Best Editing for the Carlo Verdone's film Maledetto il giorno che t'ho incontrato.
His most recent films are Mio fratello è figlio unico (2006), for which Elio Germano won the David di Donatello as best actor in a leading role, and La nostra vita (2010), which was the only Italian film selected for official competition at the 2010 Cannes Film Festival.
In 1988, his La leggenda del santo bevitore (The Legend of the Holy Drinker), based on the novel by Joseph Roth and starring Rutger Hauer, won the Golden Lion at the Venice Film Festival as well as a David di Donatello award.
In 1989 he won a David di Donatello for best supporting actor for his performance in Francesca Archibugi's Mignon è partita.
Additionally, it won awards at several other film festivals including the David Di Donatello Awards, the Satyajit Ray Award at the London Film Festival, and the Golden Snail award at the Academy of Food and Film in Bologna.
He won two David di Donatello for Best Editing in 1991 and 1992, for The Voice of the Moon and Mediterraneo.
For his performance Angelo Orlando won the David di Donatello for best supporting actor.
In 2001, Sperandeo won the David di Donatello award for Best Supporting Actor in "I cento passi" ("One Hundred Steps"), directed by Marco Tullio Giordana, in which he played the role of Mafia boss Tano Badalamenti.
1976 David di Donatello (Italian Academy Awards) Best Foreign Screenplay: The Last Tycoon (winner)