In 2001, Sperandeo won the David di Donatello award for Best Supporting Actor in "I cento passi" ("One Hundred Steps"), directed by Marco Tullio Giordana, in which he played the role of Mafia boss Tano Badalamenti.
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He has appeared in many other Italian films, the most notable being La scorta by Ricky Tognazzi, as well as "Ragazzi fuori" and "Mery per sempre", the latter two set in his home town of Palermo.
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In 1985, he landed a role in a cinematographic film Pizza Connection, by Damiano Damiani.
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