Desario formed in early 2004 when John Conley, Michael Yoas and Jim Rivas, who had played together previously in various other bands including Holiday Flyer, got together and started writing songs.
"Ain't Nothing Gonna Keep Me From You" from 1978 was DeSario's first hit single, written by Barry Gibb from her first album Pleasure Train, also released in 1978.
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Barry Gibb heard her demo of original music and was so inspired by DeSario's vocals that he wrote a song for her called "Ain't Nothing Gonna Keep Me From You" and helped her obtain a recording contract.
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In the U.S., DeSario is mainly known for her duet with KC, lead singer of the R&B and funk group KC and the Sunshine Band of the Barbara Mason cover, (Pop # 2 on the Billboard Hot 100 and certified gold, Adult Contemporary #1 for 2 weeks) "Yes, I'm Ready" from 1980, from her second album Moonlight Madness, released in 1979.