In 1956, Fabio Taglioni, a Ducati engineer, developed a desmodromic valve system for the Ducati 125 Grand Prix, creating the Ducati 125 Desmo.
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With the onset of the 800 cc era in 2007, they are generally still considered to be the most powerful engines in the sport, and have powered Casey Stoner to the 2007 MotoGP Championship and Ducati to the constructors championship with the GP7 (Desmosedici) bike.
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Firsts included the use of desmodromic valves and fuel injection developed by Mercedes engineers through experience gained on the DB 600 series of engines used on the Messerschmitt Bf 109 fighter and others during World War II.