In the Mass Effect 3 video game, 2181 Despoina is the planet occupied by a powerful ancient mind-controlling species.
The central figures of Despoina and Demeter were on a colossal scale, significantly greater than that of Artemis and the Titan Anytus.
Theodora Tocco, despoina consort of Constantine, Despot in Morea (later Constantine XI Palaiologos).