In 1977 Middlebrook began a relationship with noted scientist Carl Djerassi.
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Born Helen Diane Wood, in Pocatello, Idaho, Middlebrook spent the last 28 years of her life with her third husband, Carl Djerassi, a Viennese-born American scientist who helped invent the first contraceptive pill.
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She was noted for her diversity of study subjects; one syllabus from that era lists both Ovid and Queen Latifah.
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