Interestingly, dRTA has been proposed as a possible diagnosis for the unknown malady plaguing Tiny Tim in Charles Dickens' A Christmas Carol.
Tubular Bells | renal failure | Renal failure | End stage renal disease | Tubular Bells II | Renal Support Network | Tubular Bells III | Tubular Bells 2003 | Renal tubular acidosis | Renal function | Renal Failure | Renal cell carcinoma |
Mutations to the V-ATPase 'a4' or 'B1' isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness.
Renal tubular acidosis failure of HCO3- resorption(i.e., proximal renal tubular acidosis, or overdose of carbonic anhydrase inhibitor) or failure of H+ secretion (i.e. in distal renal tubular acidosis)