Wilson moved to NYC in 1959 where he had a brief acting career playing such roles as Valère to the Mariane of Dawn Wells (later Mary Ann on Gilligan's Island) in Molière's Tartuffe and Older Patrick to Nancy Wilder's Auntie Mame in various stock productions.
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In 1961, he became one of the first resident playwrights at NYC's legendary Caffe Cino, his comedy, And He Made a Her, opened there with Jane Lowry and Larry Neil Clayton leading the cast and Paxton Whitehead directing.
Woodrow Wilson | Harold Wilson | Pete Wilson | Woodrow Wilson International Center for Scholars | Brian Wilson | Wilson | Edmund Wilson | Owen Wilson | James Wilson | Wilson Pickett | Teddy Wilson | Richard Wilson | William Julius Wilson | Paul Wilson | John Marius Wilson | Jackie Wilson | Doric order | Cassandra Wilson | Steven Wilson | Gahan Wilson | Wilson Phillips | Carl Wilson | Richard Wilson (Scottish actor) | Mount Wilson Observatory | Mari Wilson | Julie Wilson | John Wilson | Jacqueline Wilson | Mouth of Wilson, Virginia | Gretchen Wilson |
Among those who Picano introduced to the public via his publishing companies were Dennis Cooper, Harvey Fierstein, Jane Chambers, Brad Gooch, Robert Glück, Doric Wilson, and Gavin Dillard.