:Note: Drosha is an anagram for the word "hoards", and equally irrelevant to this article about molecular biology, Drosha, or Droshah, is the Hebrew and Yiddish word for sermon in Judaism.
The genome of Mnemiopsis leidyi appears to lack recognizable microRNAs, as well as the nuclear proteins Drosha and Pasha, which are critical to canonical microRNA biogenesis.
Based on this model, her research group discovered that most microRNA genes are transcribed by RNA polymerase II and that pri-miRNA processing is carried out by Drosha-DGCR8 complexes in the nucleus.
Drosha |