He was the second but eldest surviving son of the 1st Earl of Portland, by his second wife Frances Walgrave.
The name of Bentinck came from the family name of the Earl of Portland who was then based at Welbeck Abbey in nearby Clumber Park, and the current Earl is the BBC radio actor Tim Bentinck, 12th Earl of Portland; he is best known for playing David Archer in The Archers.
Weston was elevated to the peerage on 13 April 1628, as Baron Weston, of Neyland.
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On his death, he was succeeded by his second but eldest surviving son, Jerome.
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He passed sentence of death on Lord Audley in 1631, drafted and enforced the proclamation of 20 June 1632 ordering the country gentlemen to leave London, and in 1634 joined in William Laud's attack on the Earl of Portland for peculation.