Born to Edward "Ba Ba" Orgeron Sr. (d. 2011) and Cornelia "Co Co" Orgeron, Ed and his brother Stephen grew up in Larose, a town on the Bayou Lafourche in Lafourche Parish, Louisiana.
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While he was with the Hurricanes, the program won two national championships (in 1989 and 1991), and he recruited a young Dwayne Johnson (later known as "The Rock" in his professional wrestling and film careers) as a defensive lineman.
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Director John Lee Hancock contacted Orgeron about playing himself, despite having been fired by Ole Miss prior to the filming of the movie; Orgeron agreed and impressed the filmmaker with his enthusiasm.