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His career spanned over thirty years of Mexican cinema, including films such as Mujeres salvajes and El callejón de los milagros; in addition, he had small parts in a few Hollywood movies such as Solo, The Mask of Zorro, Apocalypto, Ravenous and My Family.
Two of the most important films of his filmography are Rojo amanecer (1989) and El callejón de los milagros (1995) based in the homonym book by Naguib Mahfouz, Midaq Alley of 1947 (زقق المدق), which breaks the classic lineal plots in films.
Many of his novels were first published in serialized form, including Children of Gebelawi and Midaq Alley which was adapted into a Mexican film starring Salma Hayek (El callejón de los milagros).