As part of the European Cultural Capital festivities of Essen, he led the new productions of Henze's Elegie für junge Liebende and a concert version of Bizet's Les pêcheurs de perles.
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They also collaborated on two librettos for Henze, Elegy for Young Lovers (1961) and The Bassarids (1966), and on the libretto of Love's Labour's Lost (based on Shakespeare's play) for Nicolas Nabokov (1973).
She was also the first to sing the French version of Hans Werner Henze's Elegy for Young Lovers in 1965, and Pierre Boulez chose Mesplé for his performances of Arnold Schoenberg's Jacob's Ladder.