In South Africa, the National Minister of Health, Doctor Aaron Motsoaledi, administered to the first state patient a fixed dose combination (FDC) tablet of Emtricitabine/Tenofovir/Efavirenz on 9 April 2013 in GaRankuwa.
Elvitegravir/cobicistat/emtricitabine/tenofovir (brand name Stribild), also known as the Quad pill, is a fixed dose combination drug for the treatment of HIV/AIDS.
In 1993 Erik De Clercq and other researchers at the Rega Institute for Medical Research described the activity of tenofovir against HIV in cell culture.