Until 2008, no large EV71 epidemic had been reported on the Chinese mainland, but sporadic infections were common in the southeast coastal area as well as in inland regions, such as Beijing, Chongqing, and Jinan.
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The receptors for EV71 and CVA16 have been identified as P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2); both are transmembrane proteins.
The recent death of 64 of 66 children affected with a complex syndrome including menningitis and pneumonia in Cambodia has been linked to a multiple infection of the children with Dengue fever, Enterovirus 71 and Strep.
SCARB2 is a receptor for two viruses that cause hand, foot, and mouth disease in children, Enterovirus 71 and Coxsackievirus A16.