EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1.
Lymphedema–distichiasis syndrome is a medical condition associated with the FOXC2 gene.
FOXC2 |
SNAI1/Snail 1, SNAI2/Snail 2 (also known as Slug), ZEB1, ZEB2, E47 and KLF8 (Kruppel-like factor 8) can bind to E-cadherin promoter and repress its transcription, whereas factors such as Twist, Goosecoid, E2.2 (also known as TCF4), homeobox protein SIX1 and FOXC2 (fork-head box protein C2) repress E-cadherin indirectly.