Current research is investigating the potential of combining FOXO1 and Notch-1 haploinsufficiency in mice; preliminary results suggest that in HFD-fed mice, the combination of FOXO1 and Notch-1 haploinsufficiency was more effective at restoring insulin sensitivity than FOXO1 haploinsufficiency alone.
FOXO1 |
It can be associated with a fusion protein between PAX3 and FKHR (now known as FOXO1).