In the first series, it was revealed that "Big Brain" is a drone controlled from the Negative Zone, where Sue Storm is held in a kind of stasis.
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Reed Richards, Mr. Fantastic - Formerly the Big Brain robot, Reed has recently returned from repairing a hole in the Negative Zone caused by Hyperstorm.
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However, with the collapse of a deal to sell the comics in Kmart and Target both Fantastic Five and Wild Thing were cancelled after five issues, leaving Spider-Girl as the only title in the MC2 Universe still published.