wildpretii is known to grow on species of the globose cacti Echinocactus platyacanthus, Mammillaria carnea and Ferocactus latispinus; the opuntioid cacti Opuntia depressa, O. maxima, O. pilifera and O. tomentosa) and the columnar cacti (Myrtillocactus geometrizans, Pachycereus hollianus, P. weberi, Stenocereus and Neobuxbaumia.
The slime mold, Didymium wildpretii feeds on the decaying remains of F. latispinus in Mexico.