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His graphic novel Appunti per una Storia di Guerra (Notes pour une histoire de guerre, Notes for a War Story), published by Coconino Press, appeared in France and was published in the United States by First Second Books.
Under the banner of First Second Books, located in the Flatiron Building in New York City, Siegel is the editor of works by authors and artists such as Joann Sfar, Eddie Campbell, Paul Pope, Jessica Abel and Lewis Trondheim, Jane Yolen, and Adam Rapp.