Focal infection theory as a primary cause of systemic disease rapidly became accepted by mainstream dentistry and medicine after World War I, largely on the basis of what later turned out to be fundamentally flawed studies providing evidence to support the theory.
Scull argues that Cotton's obsession with focal sepsis as the root cause of mental illness "persisted in spite of all evidence to the contrary and the frightening incidence of death and harm from the operations he initiated".
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