With the Cubs, he created the famous Tinker to Evers to Chance infield combination, by converting Frank Chance from catcher to first base, Joe Tinker from third base to shortstop, and Johnny Evers from shortstop to second base.
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After he left Boston, he went on to manage in Chicago where built the basis for the Cubs' later success by signing and utilizing the talents of Frank Chance, Joe Tinker, and Johnny Evers.
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He was elected to the Baseball Hall of Fame in 1999 for his managerial achievements.
One day, manager Frank Selee suggested he try batting left-handed, and upon making contact with the ball, St. Vrain was confused enough to run to third base (he was thrown out at first base).
On June 30, 1892, after 16 starts and a 8–6 record, Boston's new manager, Frank Selee, released Clarkson.
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