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La Trémoille was the heir-general of Frederick IV of Naples and his first wife Anne of Savoy, and succeeded to the Cypriot claims to the title of King of Jerusalem when his father died.
Ferrantino was restored to the throne, but died in 1496, and was succeeded by his uncle, Frederick IV.
On 11 September 1478 in Milan, she married Frederick of Aragon, Prince of Squillace, Altamura and Tarento (1452–1504), the future King Frederick IV of Naples.
Isabella del Balzo (died 1533), the second wife and only Queen consort of Frederick IV of Naples