He established the first Spanish settlement in present day California, the Presidio of San Diego, and was the first European to see the San Francisco Bay.
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Two archaeological zones, of ancient Pima Indigenous people of the Americas settlement sites, are located near the village of Ojo de Agua.
In 1752 he enlisted in the army at the Presidio of Fronteras.
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Juan Bautista de Anza was born in Fronteras, Sonora, Mexico in 1736 (near Arizpe), into a military family living on the northern frontier of New Spain.